XIII
th International conference
NMR: a tool for biology
Institut Pasteur, May 15-17 2023
Monday, May 15, 2023
| Arrival, registration and poster setup |
| 08.00 am-09.00 am (GMT+1)
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| Welcome address by Prof. Michael Nilges, Vice President for Technology of Institut Pasteur |
| 09.00 am-09.15 am (GMT+1)
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| Opening remarks by Eric Leonardis (Bruker BioSpin) & Nadia Izadi-Pruneyre (Institut Pasteur) |
| 09.15 am-09.30 am (GMT+1)
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| IN-CELL NMR |
| 09.30 am-10.35 am (GMT+1)
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| Chair: François-Xavier Theillet, CNRS, Gif-Sur-Yvette, France |
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1
09.30 am (GMT+1) |
In-cell NMR: results and challenges
Lucia Banci
CERM and Department of Chemistry, University of Florence, Sesto Fiorentino, Italy
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2
10.00 am (GMT+1) |
In-cell NMR: A discovery tool for Cell Biology
Philipp Selenko
Weizmann Institute, Israel
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| Coffee break |
| 10.30 am-11.15 am (GMT+1)
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| MOLECULAR ASSEMBLIES |
| 11.15 am-12.45 pm (GMT+1)
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| Chair: Muriel Delepierre, Institut Pasteur, CNRS, Paris, France |
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3
11.15 am (GMT+1) |
Structure, dynamics and interactions of kinetochore proteins from Trypanosoma brucei
Christina Redfield
Department of Biochemistry, University of Oxford, United Kingdom
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4
11.45 am (GMT+1) |
Structure and dynamic association of bacterial filaments
Nadia Izadi-Pruneyre
Department of Structural Biology and Chemistry, CNRS UMR 3528, Institut Pasteur, Paris, France
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5
12.15 pm (GMT+1) |
Unveiling the mechanism controling assembly of bacterial focal adhesions
Latifa Elantak
Laboratoire d'ingénierie des systemes macromoléculaires, CNRS, Aix-Marseille université, Marseille, France
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| Lunch buffet and poster session |
| 12.45 pm-3.00 pm (GMT+1)
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| DYNAMIC AND DISORDERED SYSTEMS |
| 3.00 pm-4.00 pm (GMT+1)
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| Chair: Carine van Heijenoort, CNRS, Gif-Sur-Yvette, France |
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6
3.00 pm (GMT+1) |
The role of highly flexible regions in orchestrating the properties of multidomain proteins: insights from 13C detected NMR experiments
Isabella Felli
Magnetic Resonance Center (CERM) and Department of Chemistry “Ugo Schiff”, University of Florence, Sesto Fiorentino, Italy
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7
3.30 pm (GMT+1) |
Deciphering the intricate role of intrinsically disordered regions in transcription factor regulation
Tobias Madl
Medical University of Graz, Austria
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| Coffee break |
| 4.00 pm-4.45 pm (GMT+1)
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| PUSHING THE FRONTIERS OF NMR |
| 4.45 pm-6.15 pm (GMT+1)
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| Chair: Geerten Vuister, University of Leicester, United Kingdom |
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8
4.45 pm (GMT+1) |
What use are NMR structures of proteins?
Mike Williamson
School of Biosciences, University of Sheffield, United Kingdom
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9
5.15 pm (GMT+1) |
TBA
Rainer Kuemmerle
Bruker BioSpin AG, Fällanden, Switzerland
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10
5.45 pm (GMT+1) |
The Magic of Linking Rings: Discovery of a Unique Photoinduced Fluorescent Protein Crosslink
Angela Gronenborn
Department of Structural Biology, University of Pittsburgh School of Medicine, Pittsburgh, United States
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| Conference cocktail |
| 6.15 pm-8.30 pm (GMT+1)
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Tuesday, May 16, 2023
| MEMBRANE AND CARBOHYDRATE-BOUND PROTEINS |
| 09.15 am-10.45 am (GMT+1)
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| Chair: Iñaki Guijarro, Institut Pasteur, Paris, France |
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11
09.15 am (GMT+1) |
Breaking the limits in understanding glycan recognition in NMR
Jesús Jimenéz-Barbero
CIC bioGUNE, Bizkaia, Derio, Spain
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12
09.45 am (GMT+1) |
Properties of micelles, bicelles, and membranes impact on membrane protein structure and dynamics
Linda Columbus
University of Virginia, United States
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13
10.15 am (GMT+1) |
Cation Channels and Rhomboid Proteases Studied by Solid-State NMR
Adam Lange
Leibniz-Forschungsinstitut für Molekulare Pharmakologie, Berlin, Germany
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| Coffee break |
| 10.45 am-11.30 am (GMT+1)
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| METABOLOMICS |
| 11.30 am-12.30 pm (GMT+1)
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| Chair: Céline Landon, CNRS, Orléans, France |
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14
11.30 am (GMT+1) |
A journey into the human metabolome
Paola Turano
CERM and Department of Chemistry, University of Florence, Sesto Fiorentino, Italy
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15
12.00 pm (GMT+1) |
Pure Shift NMR of Aqueous Biofluids: Towards Quantitative Metabolic Profiling
Nicolas Giraud
Université Paris Cité, Paris, France
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| Lunch buffet and poster session |
| 12.30 pm-2.45 pm (GMT+1)
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| RNA AND COMPLEXES |
| 2.45 pm-4.15 pm (GMT+1)
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| Chair: Carine Tisné, CNRS-IBPC, Paris, France |
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16
2.45 pm (GMT+1) |
RNA dynamics by NMR
Katja Petzold
Dept. of Medical Biochemistry and Microbiology, Uppsala University, Sweden
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17
3.15 pm (GMT+1) |
Lifetime of Ground Conformational State Determines the Activity of Structured RNA
Qi Zhang
Department of Biochemistry and Biophysics, University of North Carolina at Chapel Hill, Chapel Hill, United States
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18
3.45 pm (GMT+1) |
Structural basis for dynamic protein-protein and protein-RNA interactions during early spliceosome assembly
Michael Sattler
Helmholtz Center Munich, Molecular Targets & Therapeutics Center, Institute of Structural Biology, Neuherberg, Germany Technical University of Munich, TUM School of Natural Sciences, Department of Bioscience, Bavarian NMR Center, Garching, Germany
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| Coffee break |
| 4.15 pm-5.00 pm (GMT+1)
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| LARGE PROTEINS |
| 5.00 pm-6.30 pm (GMT+1)
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| Chair: Sophie Zinn-Justin, CEA, Saclay, France |
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19
5.00 pm (GMT+1) |
Human HSP90 a contortionist drug target: Modulation of its energy landscape upon ligand binding
Jérome Boisbouvier
Institut de Biologie Structurale, Grenoble, France
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20
5.30 pm (GMT+1) |
Bacillus Subtilis Biofilm Formation and Investigations of (Very) Large Proteins
Hartmut Oschkinat
Leibniz-Forschungsinstitut für Molekulare Pharmakologie, Berlin, Germany Institut für Chemie und Biochemie, Freie Universitä, Berlin, Germany
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21
6.00 pm (GMT+1) |
Structural biology of telomerase mechanism and interactions at telomeres
Juli Feigon
Department of Chemistry and Biochemistry, University of California, Los Angeles, United States
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Wednesday, May 17, 2023
| VIRAL PROTEIN COMPLEXES |
| 09.00 am-10.00 am (GMT+1)
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| Chair: Guy Lippens, CNRS-INSA, Toulouse, France |
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22
09.00 am (GMT+1) |
Solid-state NMR of viral ribonucleoprotein complexes
Anja Böckmann
Molecular Microbiology and Structural Biochemistry (MMSB), UMR 5086 CNRS/Université de Lyon, Lyon, France
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23
09.30 am (GMT+1) |
NMR Provides Unique Insight into the Functional Dynamics and Interactions of Intrinsically Disordered Proteins involved in Viral Replication
Martin Blackledge
Protein Dynamics and Flexibility by NMR, Institut de Biologie Structurale UGA-CEA-CNRS, Grenoble, France
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| Coffee break |
| 10.00 am-10.30 am (GMT+1)
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| ANTIMICROBIAL AND THERAPY DEVELOPMENT |
| 10.30 am-12.30 pm (GMT+1)
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| Chair: Michael Nilges, Institut Pasteur, Paris, France |
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24
10.30 am (GMT+1) |
Uncovering the Role of DNAJB6 Chaperone Mutations in Myopathies
Rina Rosenzweig
Weizmann Institute, Israel
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25
11.00 am (GMT+1) |
The conformational landscape of protein kinases in physiology and disease
Babis Kalodimos
St Jude Hospital, Memphis, United States
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26
11.30 am (GMT+1) |
The Mechanisms of Lipid-targeting Antibiotics
Markus Weingarth
Utrecht University, The Netherlands
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27
12.00 pm (GMT+1) |
Locating antimicrobial peptides in lipid membranes and bacteria by solid-state NMR
Frances Separovic
School of Chemistry, Bio21 Institute, University of Melbourne, Australia
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| Concluding remarks by Michael Nilges |
| 12.30 pm-12.45 pm (GMT+1)
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| CCPN Satellite workshop (only for registered attendees) |
| 2.00 pm-6.00 pm (GMT+1)
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